Publications
2021
Modulation of injectable hydrogel properties for slow co‐delivery of influenza subunit vaccine components enhance the potency of humoral immunity
Saouaf, O. M.; Roth, G. A.; Ou, B. S.; Smith, A. A. A.; Yu, A. C.; Gale, E. C.; Grosskopf, A. K.; Picece, V. C. T. M.; Appel, E. A. J. Biomed., Mater. Res. (2021) PDF
Full closed loop open‐source algorithm performance comparison in pigs with diabetes
Lal, R. A.; Maikawa, C. A.; Lewis, D.; Baker, S. W.; Smith, A. A. A.; Roth, G. A.; Gale, E. C.; Stapleton, L. M.; Mann, J. L.; Yu, A. C.; Correa, S.; Grosskoph, A. K.; Liong, C. S.; Meis, C. M.; Chan, D.; Garner, J. P.; Maahs, D. M.; Buckingham, B. A.; Appel, E. A. Clin. Transl. Med. (2021) PDF
Enhanced Humoral Immune Response by High Density TLR Agonist Presentation on Hyperbranched Polymers
Liong, C. S.; Smith, A. A. A. Mann, J. L.; Roth, G. A.; Gale, E. C.; Maikawa, C. L.; Ou, B. S.; Appel, E. A. Advanced Therapeutics (2021) PDF
Dynamic Hydrogels for Prevention of Post‐Operative Peritoneal Adhesions
Stapleton, L. M.; Lucian, H. J.; Grosskopf, A. K.; Smith, A. A. A.; Totherow, K. P.; Woo, J.; Appel, E. A. Advanced Therapeutics (2021) PDF
Prolonged Codelivery of hemagglutinin and a TLR7/8 agonist in a supramolecular polymer–nanoparticle hydrogel enhances potency and breadth of influenza vaccination
Roth, G. A.; Saouaf, O. M.; Smith, A. A. A.; Gale, E. C.; Alcántara-Hernández, M.; Idoyaga, J.; Appel, E. A. ACS Biomater. Sci. Eng. (2021) PDF
Controlling properties of thermogels by tuning critical solution behaviour of ternary copolymers.
Smith, A. A. A.; Maikawa, C. L.; Hernandez, H. L.; Appel, E.A. Polym. Chem. (2021) PDF
2020
Site-Selective Modification of Proteins Using Cucurbit[7]Uril as Supramolecular Protection for N -Terminal Aromatic Amino Acids.
Smith, A. A. A.; Maikawa, C. L.; Roth, G. A. Appel, E. A. Org. Biomol. Chem. (2020) PDF
Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment.
Smith, A. A. A.; Gale, E. C.; Roth, G. A.; Maikawa, C. L.; Correa, S.; Yu, A. C.; Appel, E. A. Biomacromolecules (2020) PDF
Lipid Nanodiscs via Ordered Copolymers.
Smith, A. A. A.; Autzen, H. E.; Faust, B.; Mann, J. L.; Muir, B. W.; Howard, S.; Postma, A.; Spakowitz, A. J.; Cheng, Y.; Appel, E. A. Chem (2020) PDF
Self-Assembled, Dilution-Responsive Hydrogels for Enhanced Thermal Stability of Insulin Biopharmaceuticals.
Meis, C. M.; Salzman, E. E.; Maikawa, C. L.; Smith, A. A. A.; Mann, J. L.; Grosskopf, A. K.; Appel, E. A. ACS Biomater. Sci. Eng. 2020. PDF
An Ultrafast Insulin Formulation Enabled by High-Throughput Screening of Engineered Polymeric Excipients.
Mann, J. L.; Maikawa, C. L.; Smith, A. A. A.; Grosskopf, A. K.; Baker, S. W.; Roth, G. A.; Meis, C. M.; Gale, E. C.; Liong, C. S.; Correa, S.; Chan, D.; Stapleton, L. M.; Yu, A. C.; Muir, B.; Howard, S.; Postma, A.; Appel, E. A. Sci. Transl. Med. (2020) PDF
Structural Considerations for Physical Hydrogels Based on Polymer-Nanoparticle Interactions.
Yu, A. C.; Smith, A. A. A.; Appel, E. A. Mol. Syst. Des. Eng. (2020) PDF
Injectable Supramolecular Polymer–Nanoparticle Hydrogels Enhance Human Mesenchymal Stem Cell Delivery.
Grosskopf, A. K.; Roth, G. A.; Smith, A. A. A.; Gale, E. C.; Hernandez, H. L.; Appel, E. A. Bioeng. Transl. Med. (2020) PDF
Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity.
Roth, G. A.; Gale, E. C.; Alcántara-Hernández, M.; Luo, W.; Axpe, E.; Verma, R.; Yin, Q.; Yu, A. C.; Lopez Hernandez, H.; Maikawa, C. L.; Smith, A. A. A.; Davis, M. M.; Pulendran, B.; Idoyaga, J.; Appel, E. A. ACS Cent. Sci. (2020) PDF
A Co-Formulation of Supramolecularly Stabilized Insulin and Pramlintide Enhances Mealtime Glucagon Suppression in Diabetic Pigs.
Maikawa, C. L.; Smith, A. A. A.; Zou, L.; Roth, G. A.; Gale, E. C.; Stapleton, L. M.; Baker, S. W.; Mann, J. L.; Yu, A. C.; Correa, S.; Grosskopf, A. K.; Liong, C. S.; Meis, C. M.; Chan, D.; Troxell, M.; Maahs, D. M.; Buckingham, B. A.; Webber, M. J.; Appel, E. A. Nat. Biomed. Eng. (2020) PDF
Highly-Branched Polydimethacrylamide Copolymers as Functional Biomaterials.
Mann, J.L.; Grosskopf, A.K.; Smith, A.A.A.; Appel, E.A. Biomacromolecules (2020) PDF
2019
Use of a Supramolecular Polymeric Hydrogel as an Effective Post-Operative Pericardial Adhesion Barrier.
Stapleton, L. M.; Steele, A. N.; Wang, H.; Lopez Hernandez, H.; Yu, A. C.; Paulsen, M. J.; Smith, A. A. A.; Roth, G. A.; Thakore, A. D.; Lucian, H. J.; Totherow, K. P.; Baker, S. W.; Tada, Y.; Farry, J. M.; Eskandari, A.; Hironaka, C. E.; Jaatinen, K. J.; Williams, K. M.; Bergamasco, H.; Marschel, C.; Chadwick, B.; Grady, F.; Ma, M.; Appel, E. A.; Woo, Y. J. Nat. Biomed. Eng. (2019) PDF
Practical Prediction of Heteropolymer Composition and Drift.
Smith, A. A. A.; Hall, A.; Wu, V.; Xu, T. ACS Macro Lett. (2019) PDF Program
Universal Scaling Behavior during Network Formation in Controlled Radical Polymerizations.
Mann, J. L.; Rossi, R. L.; Smith, A. A. A.; Appel, E. A. Macromolecules (2019) PDF
Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues.
Maikawa, C. L.^; Smith, A. A. A.^; Zou, L.; Meis, C. M.; Mann, J. L.; Webber, M. J.; Appel, E. A. Advanced Therapeutics (2019) PDF
A Nanoparticle Platform for Improved Potency, Stability, and Adjuvanticity of Poly(I:C).
Gale, E.C.; Roth, G. A.; Smith, A. A. A.; Alcántara-Hernández, M.; Idoyaga, J.; Appel, E. A. Advanced Therapeutics (2019) PDF
2018
Random Heteropolymers Preserve Protein Function in Foreign Environments.
Panganiban, B.; Qiao, B.; Jiang, T.; DelRe, C.; Obadia, M. M.; Nguyen, T. D.; Smith, A. A. A.; Hall, A.; Sit, I.; Crosby, M. G.; Dennis, P. B.; Drockenmuller, E.; De La Cruz, M. O.; Xu, T. Science (2018) PDF
2017
Controlling Styrene Maleic Acid Lipid Particles through RAFT.
Smith, A. A. A.; Autzen, H. E.; Laursen, T.; Wu, V.; Yen, M.; Hall, A.; Hansen, S. D.; Cheng, Y.; Xu, T. Biomacromolecules (2017) PDF
2016
HIV Anti-Latency Treatment Mediated by Macromolecular Prodrugs of Histone Deacetylase Inhibitor, Panobinostat.
Zuwala, K.; Smith, A. A. A.; Tolstrup, M.; Zelikin, A. N. Chem. Sci. (2016) PDF
Triple Activity of Lamivudine Releasing Sulfonated Polymers against HIV-1.
Danial, M.; Andersen, A. H. F.; Zuwala, K.; Cosson, S.; Riber, C. F.; Smith, A. A. A.; Tolstrup, M.; Moad, G.; Zelikin, A. N.; Postma, A. Mol. Pharm. (2016) PDF
Albumin-Polymer-Drug Conjugates: Long Circulating, High Payload Drug Delivery Vehicles.
Smith, A. A. A.; Zuwala, K.; Pilgram, O.; Johansen, K. S.; Tolstrup, M.; Dagnaes-Hansen, F.; Zelikin, A. N. ACS Macro. Lett. PDF
2015
Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs.
Riber, C. F.; Smith, A. A. A.; Zelikin, A. N. Adv. Healthc. Mater. (2015) PDF
Macromolecular Prodrugs of Ribavirin: Towards a Treatment for Co-Infection with HIV and HCV.
Smith, A. A. A.; Zuwala, K.; Kryger, M. B. L.; Wohl, B. M.; Guerrero-Sanchez, C.; Tolstrup, M.; Postma, A.; Zelikin, A. N. Chem. Sci. (2015) PDF
Polymers Fight HIV: Potent (Pro)Drugs Identified Through Parallel Automated Synthesis.
Zuwala, K.; Smith, A. A. A.; Postma, A.; Guerrero-Sanchez, C.; Ruiz-Sanchis, P.; Melchjorsen, J.; Tolstrup, M.; Zelikin, A. N. Adv. Healthc. Mater. (2015) PDF
Highly Active Macromolecular Prodrugs Inhibit Expression of the Hepatitis c Virus Genome in the Host Cells.
Ruiz-Sanchis, P.; Wohl, B. M.; Smith, A. A. A.; Zuwala, K.; Melchjorsen, J.; Tolstrup, M.; Zelikin, A. N. Adv. Healthc. Mater. (2015) PDF
Phospholipid-Polymer Amphiphile Hybrid Assemblies and Their Interaction with Macrophages.
Panneerselvam, K.; Lynge, M. E.; Riber, C. F.; Mena-Hernando, S.; Smith, A. A. A.; Goldie, K. N.; Zelikin, A. N.; Städler, B.. Biomicrofluidics (2015) PDF
Routing of Individual Polymers in Designed Patterns.
Knudsen, J. B.; Liu, L.; Kodal, A. L. B.; Madsen, M.; Li, Q.; Song, J.; Woehrstein, J. B.; Wickham, S. F. J.; Strauss, M. T.; Schueder, F.; Vinther, J.; Krissanaprasit, A.; Gudnason, D.; Smith, A. A. A.; Ogaki, R.; Zelikin, A. N.; Besenbacher, F.; Birkedal, V.; Yin, P.; Shih, W. M.; Jungmann, R.; Dong, M.; Gothelf, K. V. Nat. Nanotechnol. (2015) PDF
2014
Macromolecular Macromolecular Prodrugs for Controlled Delivery of Ribavirin.
Kryger, M. B. L.; Smith, A. A. A.; Wohl, B. M.; Zelikin, A. N. Macromol. Biosci. (2014) PDF
Disulfide Reshuffling Triggers the Release of a Thiol-Free Anti-HIV Agent to Make up Fast-Acting, Potent Macromolecular Prodrugs.
Kock, A.; Zuwala, K.; Smith, A. A. A.; Ruiz-Sanchis, P.; Wohl, B. M.; Tolstrup, M.; Zelikin, A. N. Chem. Commun. (2014) PDF
Macromolecular (pro)Drugs in Antiviral Research.
Smith, A. A. A.; Kryger, M. B. L.; Wohl, B. M.; Ruiz-Sanchis, P.; Zuwala, K.; Tolstrup, M.; Zelikin, A. N. Polym. Chem. (2014) PDF
Cholesterol Modification of (Bio)Polymers Using UV-Vis Traceable Chemistry in Aqueous Solutions.
Rasmussen, K. F.; Smith, A. A. A.; Ruiz-Sanchis, P.; Edlund, K.; Zelikin, A. N. Macromol. Biosci. (2014) PDF
Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug.
Smith, A. A. A.; Wohl, B. M.; Kryger, M. B. L.; Hedemann, N.; Guerrero-Sanchez, C.; Postma, A.; Zelikin, A. N. Adv. Healthc. Mater. (2014) PDF
Macromolecular (pro)Drugs with Concurrent Direct Activity against the Hepatitis C Virus and Inflammation.
Wohl, B. M.; Smith, A. A. A.; Jensen, B. E. B.; Zelikin, A. N. J. Control. Release (2014) PDF
2013
Bioresorbable Surface-Adhered Enzymatic Microreactors Based on Physical Hydrogels of Poly(Vinyl Alcohol).
Fejerskov, B.; Smith, A. A. A.; Jensen, B. E. B.; Hussmann, T.; Zelikin, A. N. Langmuir (2013) PDF
Macromolecular Prodrugs of Ribavirin Combat Side Effects and Toxicity with No Loss of Activity of the Drug.
Kryger, M. B. L.; Wohl, B. M.; Smith, A. A. A.; Zelikin, A. N. Chem. Commun. (2013) PDF
Microstructured, Functional PVA Hydrogels through Bioconjugation with Oligopeptides under Physiological Conditions.
Chong, S.-F.; Smith, A. A. A.; Zelikin, A. N. Small (2013) PDF
Narrow Therapeutic Window of Ribavirin as an Inhibitor of Nitric Oxide Synthesis Is Broadened by Macromolecular Prodrugs.
Wohl, B. M.; Smith, A. A. A.; Kryger, M. B. L.; Zelikin, A. N. Biomacromolecules (2013) PDF
Liposomes as Drug Deposits in Multilayered Polymer Films.
Lynge, M. E.; Baekgaard Laursen, M.; Hosta-Rigau, L.; Jensen, B. E. B.; Ogaki, R.; Smith, A. A. A.; Zelikin, A. N.; Städler, B. ACS Appl. Mater. Interfaces (2013) PDF
2012
Macromolecular Design of Poly(Vinyl Alcohol) by RAFT Polymerization.
Smith, A. A. A.; Hussmann, T.; Elich, J.; Postma, A.; Alves, M.-H.; Zelikin, A. N. Polym. Chem. (2012) PDF
2011
Poly(Vinyl Alcohol) Physical Hydrogels: Noncryogenic Stabilization Allows Nano- and Microscale Materials Design.
Jensen, B. E. B.; Smith, A. A. A.; Fejerskov, B.; Postma, A.; Senn, P.; Reimhult, E.; Pla-Roca, M.; Isa, L.; Sutherland, D. S.; Städler, B.; Zelikin, A. N. Langmuir (2011) PDF
Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial.
Alves, M.-H.; Jensen, B. E. B.; Smith, A. A. A.; Zelikin, A. N. Macromol. Biosci. (2011) PDF